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Pool chlorine hypothesis
The pool chlorine hypothesis is the hypothesis that long-term attendance at indoor chlorinated swimming pools by children up to the age of about 6–7 years is a major factor in the rise of asthma in rich countries since the late twentieth century. A narrower version of the hypothesis, i.e. that asthma may be induced by chlorine related compounds from swimming pools, has been stated based on a small numbers of cases at least as early as 1995. An empirically motivated statement of the wider form of the hypothesis is first known to have been published on the basis of tests of the effects of nitrogen trichloride above chlorinated water on the lung 〔 as well as epidemiological evidence by a group of medical researchers led by Alfred Bernard of the Department of Public Health in the Catholic University of Louvain in Brussels, Belgium in 2003. In the epidemiological studies, the association between chlorinated swimming pools and asthma was found to be more significant than factors such as age, sex, ethnic origin, socioeconomic status, exposure to domestic animals and passive smoking (in a study in Brussels〔), and independent of altitude, climate, and GDP per capita (in a Europe-wide study of 21 countries).
==Effects of nitrogen trichloride (trichloramine) on the human lung==
Nitrogen trichloride has been directly linked as a factor causing asthma in two lifeguards and a swimming teacher. A study of 624 swimming pool workers found a significant correlation between upper respiratory symptoms and their total exposure to nitrogen trichloride. The study also found an excess risk in the workers for the specific symptoms indicative of asthma. In a study by Alfred Bernard's group, two hours exposure to an average concentration of 0.490 mg/m3 of nitrogen trichloride above a swimming pool was found in both children and adults to significantly increase the levels of the alveolar surfactant associated proteins A and B, which indicate hyperpermeability of lung epithelium.〔 In other words, exposure to nitrogen trichloride was found to weaken the protective nature of the surface of the lungs.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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